What are some characteristics and features of your cardiomyocytes?

Our Datasheet provides characterization details about iCell® Cardiomyocytes. Differentiated from human iPSCs, iCell Cardiomyocytes exhibit a stable, human cardiac gene expression profile with proper protein expression and localization necessary for cardiac function. Ma et al. (2011) determined the cell population as approximately 50% ventricular, 25% atrial, and 25% nodal by examining the action potential morphology using manual patch clamp. Babiarz et al. (2012), Kattman et al. (2010), Guo et al. (2011), and Lee et al. (2012) provided more characterization details.

For more details about about specific characterization topics, see the related Solutions, below.

References:

  1. iCell Cardiomyoctes Data Sheet
  2. Ma et al (2011) High purity Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Electrophysiological Properties of Action Potentials and Ionic Currents
  3. Babiarz et al (2012) Determination of the human cardiomyocyte mRNA and miRNA differentiation network by fine-scale profiling
  4. Kattman et al (2010) Stem Cells and Their Derivatives: A Renaissance in Cardiovascular Translational Research
  5. Guo et al (2011) Estimating the Risk of Drug-induced Proarrhythmia Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes
  6. Lee et al (2012) Simultaneous Voltage and Calcium Mapping of Genetically Purified Human Induced Pluripotent Stem Cell-derived Cardiac Myocyte Monolayers