The CIRM Induced Pluripotent Stem Cell (iPSC) Repository is a collection of stem cells produced from samples obtained from thousands of individuals. This repository provides researchers with access to cells to study how a disease develops and progresses and to facilitate the discovery and testing of new drugs or other therapies. The large size of the collection makes it a powerful resource for studying genetic variation between individuals, helping scientists to understand how disease and treatment may vary in a diverse population. What makes these samples unique?
- Non-integrating episomal reprogramming
- Reprogramming and quality control performed by a single entity
- Majority of donors screened and negative for HIV, HBV, and HCV
- Demographic and clinical data available
Diseased and Control iPSC Lines Currently Available
Below are the sample counts for the currently available lines in the CIRM iPSC Repository. New donor samples and disease cohorts are added continuously. Thus, for the most accurate sample counts, see the CIRM search tool.
| Group | Disease | Donor Samples | Control Samples |
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| Neurodevelopmental Disorders | Autism Spectrum Disorder | 113 | 175 |
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| Cerebral Palsy | 19 | ||
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| Intellectual Disability | 60 | ||
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| Epilepsy | 47 | ||
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| Liver Diseases | HCV | 93 | 17 |
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| NASH and Steatosis | 38 | ||
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| Heart Diseases | Cardiomyopathies (Dilated, Hypertrophic, ARVC, LNVC) | 442 | 10 |
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| Neurodegenerative Diseases | Alzheimer's Disease | 65 | 100 |
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| Blinding Eye Diseases | Age-related Macular Degeneration | 120 | |
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| Primary Open Angle Glaucoma | 21 | ||
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| Diabetic Retinopathy | 34 | ||
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| Lung Diseases | Pulmonary Fibrosis | 191 | |
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