Neurodegenerative Diseases: Biology & Therapeutics

The eleventh meeting on Neurodegenerative Diseases is fully virtual and will begin late morning EST on Wednesday, December 2, and will conclude late afternoon EST on Friday, December 4, 2020.

A primary goal of the meeting is to provide a forum where biomedical scientists from academia can interact with scientists from the biopharmaceutical industry, thus forging a community of academic and industry researchers who recognize that they have much to learn from each other. Rational drug discovery for neurodegenerative diseases has begun to yield compounds and treatments that are now entering clinical settings. For human studies utilizing these compounds and treatments to be maximally informative, it is crucial that scientists from academia and industry meet regularly to exchange data and ideas.

This meeting will consist of six oral sessions plus a poster session throughout the meeting. Oral sessions will include a combination of invited speakers and talks selected from submitted abstracts.

FCDI Poster Presentation

Characterization of Network Activity and Response to Neurotoxins in iPSC-derived Motor Neurons

Ali Fathi*, Rachel Lewis, Kiranmayee Bakshy, Steve Smith, Coby Carlson, and Jing Liu, FUJIFILM Cellular Dynamics, Inc.
*presenting author

Human iPSC-derived motor neurons (iCell® Motor Neurons) offer a developmentally and physiologically relevant in-vitro model of human spinal motor neurons. iCell Motor Neurons are a highly pure population of neurons as measured by Isl-1/2 and Tuj1-positive staining and they express all the necessary genes and proteins for making functional synapses and secretion / release of acetylcholine. Furthermore, iCell Motor Neurons can develop functional networks and display spontaneous calcium oscillations. Investigation of motor neurons (MNs) in co-culture with iCell Astrocytes revealed that neuronal network formation was more highly developed in the presence of glial cells, as indicated by earlier and enhanced synchronous bursting compared to mono-culture. More importantly, these cultures respond to relevant pharmacology, including the neurotoxins Botulinum (BoNT/A) and Bungarotoxin, as well as glutamate receptor blockers and glycinergic receptor antagonists.

Event Details:

Event Date: 2020-12-02 To 2020-12-04

Organiser: Cold Spring Harbor Laboratory