The availability of donor-specific iPS cells, coupled with gene-editing techniques and genome-wide association studies (GWAS), has provided new insights into the molecular basis and mechanisms of human diseases. To facilitate the rapid and reproducible implementation of cellular disease models in vitro, FUJIFILM Cellular Dynamics provides differentiated iPSC-derived cell types that are cryopreserved. These cells can be produced from a diverse bank of iPS cell lines, including diseased genotypes as well as donor cohorts.
Advantages of iPS cell disease modeling technology:
- Choice in genetic background: Biologically relevant human differentiated cells available from a diverse collection including diseased lines and isogenic controls
- Reproducible material: High purity and rigorous quality control testing ensure the same performance with every batch of cells.
- Rapid results: Cryopreserved cells eliminate the need to differentiate. Just thaw, plate, and assay.
- Flexibility: Find ways to creatively insert iPSC-derived cell types into co-culture systems and microphysiological devices.
Diseases can be modeled with iPSC-derived cells through a variety of methods:
iPS cells are generated from donors harboring specific disease genotypes and subsequently differentiated into cell types associated with the disease of interest
iPS cells have a disease-specific mutation introduced via gene editing technologies from an apparently healthy normal (AHN) donor iPS cells to create a disease genotype.
Other disease states are induced by subjecting AHN iPSC-derived cell types to specific culture conditions (e.g. diabetic media or the addition of exogenous stimuli).