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Astrocytes are specialized glial cells and the most abundant cell type in the central nervous system (CNS). Astrocytes have historically been regarded as support cells for neural tissue, with reactive astrocytes serving as markers for damaged or diseased tissue. However, new studies reveal that astrocytes play an essential and complex role in the maintenance of a healthy CNS and in the onset and development of CNS disease.
CDI’s iCell® Astrocytes are human iPS cell-derived astrocytes. They provide a readily accessible, consistent, and biologically relevant source of astrocytes for the study of synaptic transmission and plasticity in normal CNS function and disease progression. Benefits include:
Our specialists are here to help you find the best product for your application.
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Our specialists are here to help you find the best product for your application.
Our regular business hours are 9:00am to 5:00pm Central Time (USA)
A highly pure astrocyte population, iCell Astrocytes show (A) typical morphology and (B) expression of GFAP. Upon stimulation with TNFa, IL-1ß, and IFNɣ, iCell Astrocytes demonstrate (C) changes in cell morphology (stained with GFAP, green) and (D) upregulation of the IL-6 secretion, a pro-inflammatory cytokine.
Figure 1: iCell Astrocytes Exhibit Characteristics of Native Human Astrocytes
Assayed as a pure culture of astrocytes or as a co-culture with other iCell neural cell types, iCell Astrocytes provide multiple layers of biologic complexity to enable the interrogation of the following: Normal CNS functions
Three-dimensional Brain-on-chip Model Using Human iPSC-derived GABAergic Neurons and Astrocytes: Butyrylcholinesterase Post-treatment for Acute Malathion Exposure Liu L, Koo Y, Russell T, Gay E, Li Y, Yun Y PLoS One. (2020) 15(3): e0230335. (2020)
Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) Acutely Affect Human α1β2γ2L GABAA Receptor and Spontaneous Neuronal Network Function in Vitro A Tukker, L Bouwman, R van Kleef, H Hendriks, J Legler, R Westerink. (2020) Sci. Rep. 10, 5311 (2020)
Towards Animal-Free Neurotoxicity Screening: Applicability of hiPSC-derived Neuronal Models for in Vitro Seizure Liability Assessment A Tukker, R van Kleef, F Wijnolts, A De Groot, R Westerink. (2020) ALTEX. 37(1):121-135. (2020)
Excess Glutamate Secreted from Astrocytes Drives Upregulation of P-glycoprotein in Endothelial Cells in Amyotrophic Lateral Sclerosis Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, and Trotti D. (2019) Exp Neurol. 316:27-38 (2019)
Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models Lundin A, Delsing L, Clausen M, Ricchiuto P, Sanchez J, Sabirsh A, Ding M, Synnergren J, Zetterberg H, Brolén G, Hicks R, Herland A, Falk A (2018) Stem Cell Reports 10(3):1030-1045. (2018)