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iCell Cardiomyocytes^2, 11713
Product Overview
iCell® Cardiomyocytes2 are an enhanced version of the extensively validated and predictive iCell Cardiomyocytes product. Derived from induced pluripotent stem cells (iPSCs), iCell Cardiomyocytes2 from FUJIFILM Cellular Dynamics, have been optimized for high-throughput applications.
- Rapid Results iCell Cardiomyocytes2 are optimized for rapid recovery from cryopreservation and are assay-ready as early as 7 days post-thaw. The cells are provided with complete plating and maintenance medium.
- Minimal Handling iCell Cardiomyocytes2 require a limited number of hands-on steps, thereby reducing lab time and potential for contamination.
- Verified Model for Cardiac Safety Assessment iCell Cardiomyocytes2 display intact human cardiac biology with electrophysiological and biochemical responses upon exposure to exogenous agents. The cells are a preferred cellular model for cardiac safety assessment included in the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative.
- Fully Supported Optimized protocols for functional assays, which include multielectrode array (MEA), calcium handling, and impedance, enable robust and reproducible measurements of compound-induced effects on human cardiomyocyte physiology. FCDI’s application scientists provide relevant training and timely assistance to support seamless implementation.
Components:
Catalog #G11713
iCell Cardiomyocytes^2, 11713,
- Cryopreserved iCell Cardiomyocytes2, 11712
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Need Help With This Product?
Our specialists are here to help you find the best product for your application.
Our regular business hours are 9:00am to 5:00pm Central Time (USA)
Technical Docs
PROTOCOLS
Application Protocols
Measuring Cardiac Activity: Functional Maturation on the xCELLigence RTCA ePacer
Application Protocols
Measuring Cardiac Activity: Impedance Detection with xCELLigence RTCA Cardio System
Application Protocols
Measuring Cardiac Activity: Impedance and Extracellular Field Potential Detection with CardioExcyte 96 System
Application Protocols
Measuring Cardiac Activity: Impedance and Extracellular Field Potential Detection with xCELLigence RTCA CardioECR System
Application Protocols
Measuring Cardiac Activity: Intracellular Calcium Flux Detection with FDSS/µCELL
Application Protocols
Measuring Cardiac Contractility with FLEXcyte 96 System
Application Protocols
Measuring Cardiac Electrical Activity: Field Potential Detection on the Maestro Multielectrode Array
Application Protocols
Plating iCell Cardiomyocytes2 on CELLvo™ Matrix Plus
Application Protocols
Using LEAP to Measure Cardiac Action Potential Morphology
Application Protocols
Using Liposome-mediated Transfection for Gene Delivery
USER DOCS
Biosafety Document
Biosafety Document: iCell Cardiomyocytes2, 11713
Datasheet
iCell Cardiomyocytes2
Safety Data Sheet
iCell Cardiomyocytes Maintenance Medium, iCell Cardiomyocytes Plating Medium Safety Data Sheet - Asia
Safety Data Sheet
iCell Cardiomyocytes Maintenance Medium, iCell Cardiomyocytes Plating Medium Safety Data Sheet - Europe
Safety Data Sheet
iCell Cardiomyocytes Maintenance Medium, iCell Cardiomyocytes Plating Medium Safety Data Sheet - Germany
Safety Data Sheet
iCell Cardiomyocytes Maintenance Medium, iCell Cardiomyocytes Plating Medium Safety Data Sheet - North America
Safety Data Sheet
iCell Cell-Based Products Safety Data Sheet - Asia
Safety Data Sheet
iCell Cell-Based Products Safety Data Sheet - Germany
Safety Data Sheet
iCell Cell-Based Products Safety Data Sheet - North America
User's Guides
iCell Cardiomyocytes2
Performance Data
iCell Cardiomyocytes2 Provide an Accurate System for Detecting Ion Channel
Panels A and B show the expected increase in the field potential duration blocking IKr with E-4031. Panels C and D show the expected decrease in the field potential duration blocking the L-type calcium channels with NI. iCell Cardiomyocytes2 were exposed to the indicated compounds at the concentrations listed and the effects quantified ± SEM.
Figure 1: iCell Cardiomyocytes2 Provide an Accurate System for Detecting Ion Channel
Figure 2: iCell Cardiomyocytes2 Capture Phenotypic Responses across Different Classes of Cardioactive Compounds
iCell Cardiomyocytes2 Capture Phenotypic Responses across Different Classes of Cardioactive Compounds
iCell Cardiomyocytes2 Provide an Accurate System for Detecting Ion Channel Block
Panels A and B show the expected increase in the field potential duration blocking IKr with E-4031. Panels C and D show the expected decrease in the field potential duration blocking the L-type calcium channels with NI. iCell Cardiomyocytes2 were exposed to the indicated compounds at the concentrations listed and the effects quantified ± SEM.
Figure 3: iCell Cardiomyocytes2 Provide an Accurate System for Detecting Ion Channel Block
Product Highlights
A Multitude of Applications
iCell Cardiomyocytes2 have demonstrated utility for electrophysiological and biochemical assays in toxicology, drug discovery, and basic life science research applications. Contact our Technical Support team for information on using iCell Cardiomyocytes2 in these types of studies.
- Multielectrode array (MEA) recordings
- Impedance-based measurements
- Calcium flux assays with the FDSS/µCELL Functional Drug Screening System
- Liposome-mediated transfection