September 2014

SEPTEMBER 2014

Welcome to our monthly enewsletter, CDI Notebook, focused on keeping you abreast of the latest innovations using CDI's iCell^® and MyCell^® products.

In this issue:
Webinars
Publications
Conference News
Application Notes/Protocols
Presentations/Posters
Press

Webinars

Microscale Engineering Strategies to Functionally Mature iPSC-derived Human Hepatocytes (Sep 18 | 2:00 - 3:00 pm ET | Free). Learn how iCell Hepatocytes cultured in an engineered micropatterned co-culture platform enhances their functional application in drug metabolism and toxicity assessment. Presenter: Dr. Salman Khetani, Colorado State University

Registration>>

Using Induced Pluripotent Stem Cells in Drug Discovery (Sep 18 | 2:30 - 4:00 pm ET | Free). Hear case studies from and ask questions of expert panelists as they share perspectives on using iPSCs in drug discovery research. Panelists: Dr. Timothy J. Kamp, University of Wisconsin, and Dr. Steve Stice, University of Georgia

Registration>>

Publications

Examining the Protective Role of ErbB2 Modulation in Human-induced Pluripotent Stem Cell-derived Cardiomyocytes. See NIH research data supporting the utility of iCell Cardiomyocytes for discovering mechanisms of cardioprotection.

Eldridge S, Guo L, et al. (2014) Toxicol Sci.

Article>>

Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells. Find out how iCell Endothelial Cells, cultured within several bioengineered platforms mimicking the in vivo microenvironment, formed vascular architecture to enable tissue engineering and discovery applications.

Belair DG, Whisler JA, et al. (2014) Stem Cell Rev and Rep.

Article>>

Thymoquinone Protects Cultured Hippocampal and Human Induced Pluripotent Stem Cells-derived Neurons against α-synuclein-induced Synapse Damage. Read how iCell Neurons enabled assessing the neuroprotective effects of thymoquinone, a potential therapeutic agent for persons with Parkinson’s disease or dementia, against α-synuclein-induced synaptic toxicity.

Alhebshi AH, Odawara A, et al. (2014) Neurosci Lett 570:126-131.

Article>>

Conference News

CDI European User Group Meeting (Oct 6 | London | Free). Register today to attend this multisession workshop where you'll learn how iCell technology is advancing innovation at pharma, academic, and biotech institutions. Hurry, space is limited!

Agenda & Registration>>

iCell DopaNeurons – Immunofluorescent Labeling. Details how to stain iCell DopaNeurons for the presence and subcellular localization of select molecular markers.

Protocol>>

iCell Cardiomyocytes – Measuring Cardiac Activity: Intracellular Calcium Flux Detection on the FLIPR Tetra System. Provides basic instructions for cell culture, compound treatment, data acquisition, and data analysis utilizing iCell Cardiomyocytes and a FLIPR Tetra System (Molecular Devices).

Protocol>>

Presentations/Posters

Check out the following posters, presented at recent meetings, now accessible online:

• Application of Human iPSC-derived Cardiomyocytes and Neurons Using the MEA Technology (NMI MEA Meeting)

Poster>>

• Development and Characterization of Human iPSC-derived Midbrain Dopaminergic Neurons for Drug Discovery (FENS Forum)

Poster>>

Press

Cellular Dynamics Granted Patent for Automated Production of Cells (Milwaukee Journal Sentinel). Learn about CDI's latest patent covering a unique process to manufacture cells in the quantity, quality, purity, and diversity required for drug discovery, stem cell banking, and cell therapeutics research.

Article>>