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Astrocytes are specialized glial cells and the most abundant cell type in the central nervous system (CNS). Astrocytes have historically been regarded as support cells for neural tissue, with reactive astrocytes serving as markers for damaged or diseased tissue. However, new studies reveal that astrocytes play an essential and complex role in the maintenance of a healthy CNS and in the onset and development of CNS disease.
CDI’s iCell® Astrocytes are human iPS cell-derived astrocytes. They provide a readily accessible, consistent, and biologically relevant source of astrocytes for the study of synaptic transmission and plasticity in normal CNS function and disease progression. Benefits include:
A highly pure astrocyte population, iCell Astrocytes show (A) typical morphology and (B) expression of GFAP. Upon stimulation with TNFa, IL-1ß, and IFNɣ, iCell Astrocytes demonstrate (C) changes in cell morphology (stained with GFAP, green) and (D) upregulation of the IL-6 secretion, a pro-inflammatory cytokine.
Assayed as a pure culture of astrocytes or as a co-culture with other iCell neural cell types, iCell Astrocytes provide multiple layers of biologic complexity to enable the interrogation of the following: Normal CNS functions