iCell GABANeurons APP A673V, 01279

Kit Size

Catalog #: R1161

Cells Only

Catalog #: C1168
Catalog #: C1168

Alzheimer's Disease differentiated from human iPS cells, frozen

From
$2,495.00
Catalog # PA673V

Product Overview

Genetic mutations in amyloid precursor protein (APP) have been found to contribute to the early-onset or prevention of Alzheimer’s disease. The A673V variant of APP is associated with early-onset familial Alzheimer’s disease. The contribution of APP A673V to Alzheimer’s pathology is suggested to involve an elevated affinity to β-secretase, increased amyloid-beta (Aβ) production, Aβ aggregation, and neural toxicity.

iCell GABANeurons APP A673V were developed as a cellular model to investigate the genetic predisposition to early-onset Alzheimer’s Disease using a clinically relevant familial APP variant. The heterozygous mutation was engineered into apparently healthy normal induced pluripotent stem cells, followed by differentiation into cortical neurons that exhibit a majority GABAergic phenotype.

Additionally, iCell GABANeurons APP A673T cells with the protective APP variant are ideal for studying genetic protection against Alzheimer’s disease.

Features of iCell GABANeurons A673V:

  • Fully differentiated: ≥95% pure neuronal population with a majority of GABAergic neurons
  • Engineered for heterozygous A673V mutation
  • Altered neural activity phenotype compared to isogenic control
  • Expresses Tau, APP, and amyloid beta isoforms
  • Aβ levels can be modulated by drugs treatments
  • Consistent lot-to-lot GABA phenotypes and cell viability
  • Isogenic iCell GABANeurons, 01279 are available

View all Alzheimer’s disease cell models here.

Components:

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Our specialists are here to help you find the best product for your application.

Our regular business hours are 9:00am to 5:00pm Central Time (USA)

Product Highlights

Applications:

Biologically relevant disease model

iCell GABANeurons APP A673V are engineered for an Alzheimer’s disease-associated gene mutation that provides a uniquely relevant biological Alzheimer’s disease model.

Highly pure human cells

Terminally differentiated from human iPS cells, iCell GABANeurons APP A673V are ≥95% pure neuronal population with a majority of GABAergic neurons.

High throughput reproducibility

Commercial quantities of consistent GABA phenotype batches ensure reproducible large-scale drug screening programs.

Easy to implement

iCell GABANeurons APP A673V are shipped cryopreserved with optimized media. Simply thaw and use.