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(A) Cells are thawed and plated into the collagen-coated cell culture plate to form a 2D confluent monolayer. (B) Cells are then detached and seeded in aULA plate to form 3D spheroids within 2 days. See the application protocol for details.
The hepatocytes exhibit cobblestone morphology, round nuclei with distinct nucleoli, bi-nucleation (ovals), and formation of bile canaliculi (arrows).*
The hepatocytes exhibit robust (A) CYP3A basal activity and (B) CYP3A4 induction activity (response to rifampin measured by P450-Glo™ CYP3A4 Induction/Inhibition Assay, Promega Corp.).
The hepatocytes exhibit expression of (A) alpha-1-antitrypsin and (B) albumin, (C) albumin production (measured by ELISA), (D) glycogen storage (measured by PAS staining), and lipid storage (data not shown).
iCell Hepatocytes 2.0 have been genotyped for 1,936 ADME markers in over 200 genes, including all FDA-validated genes and >90% of the ADME Core markers as defined by the PharmaADME group.
iCell Hepatocytes 2.0 are platable and maintain hepatocyte functions in culture for at least one week.
iCell Hepatocytes are >95% pure, providing biologically relevant and reproducible results.
iCell Hepatocytes 2.0 are terminally differentiated from human iPS cells and exhibit hepatocyte characteristics and functions.