What are the purity and population distribution of your neurons?

Each iCell® GABANeurons Kit has >90% purity, as measured by flow cytometry for βIII-tubulin (+) and nestin (-) markers. The mixed population is comprised of approximately 70% GABAergic (inhibitory) and 30% glutamatergic (excitatory) neurons, based on biochemical and electrophysiological data. iCell DopaNeurons are more excitatory, so the balance is shifted towards more glutamatergic populations. Within this population is a sub-fraction of cholinergic receptors, such as the nicotinic acetylcholine receptors (nAChRs), as characterized by Chatzidaki et al. (2015) and Gill et al. (2013).


  1. iCell GABANeurons User's Guide
  2. iCell GABANeurons Product Page
  3. Chatzidaki et al. (2015) Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-derived Neurons
  4. Gill et al. (2013) Contrasting Properties of α7-selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors