Using Patient Specific iPSC-Cardiomyocytes for Disease Modeling

Ulrich Broeckel, MD, Medical College of Wisconsin
Presented at the SLAS 2015

Left ventricular hypertrophy (LVH) is a common, complex, and independent risk factor for cardiovascular disease. This tutorial covers translating LVH from the clinic into the discovery laboratory through generating populations of patient-specific iPSC-cardiomyocytes, identifying unique pathophysiological markers, and implementing novel high-throughput screening methodologies. Ultimately, discovery and screening approaches that utilize clinical cohorts will generate more effective therapeutic approaches as they can account for population variances in both disease manifestation and intervention response.

(Feb 10, 2015)