FUJIFILM Cellular Dynamics
September 2020
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Articles
Cellular Dynamics

Repolarization Studies Using Human Stem Cell-Derived Cardiomyocytes: Validation Studies and Best Practice Recommendations

See this informative overview on the use of human iPSC-derived cardiomyocytes for the prediction of cardiotoxicity. The article does a deep dive on methodology, cell characterization and best practices for using iCell® Cardiomyocytes for safety pharmacology.

Gintant G, Kaushik EP, Feaster T, et al. (2020) Regul Toxicol Pharmacol. 2020;117:104756.

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Cellular Dynamics

Modeling Alpha-Synuclein Pathology in a Human Brain-Chip to Assess Blood-Brain Barrier Disruption in Parkinson's Disease

See this preprint article where human iPSC-derived iCell® DopaNeurons were combined with other cells to construct a Brain-on-Chip model of the substantia nigra region of the brain to model key aspects of Parkinson's disease including inflammation and alpha-synuclein accumulation.

Pediaditakis I, Kodella KR, et al. (2020) bioRxiv 2020.07.22.207340.

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Upcoming Events
Cellular Dynamics

SPS 2020 Virtual Event (Sep 14 - 17).

See these FCDI-related poster presentations from the Safety Pharmacology Society 2020 Virtual Event:

  • Mechanical Stimulation in a 2D High-Throughput Contractility System Induces Functional Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
  • Expanding the Number of Validated iPSC-Derived Cardiomyocytes for Safety Pharmacology Studies

SEE MEETING DETAILS >>

Cellular Dynamics

Webinar: A Footprint-Free In Vitro Human iPSC Model for Drug Discovery and Safety Pharmacology: iCell Cardiomyocytes2, 11713
(Oct 20 | 11:00AM EDT).

Learn about footprint-free iCell Cardiomyocytes2 11713 and their response to the CiPA-28 reference compounds, using a new protocol that enables quantitation of action potential morphology, as well as automated detection and classification of arrhythmias.

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Cellular Dynamics

Webinar: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays
(Oct 15 | 11:00AM EDT).

Learn how HD-MEAs were used to characterize and compare human induced pluripotent stem cell (iPSC) derived dopaminergic and motor neurons, including isogenic neuronal lines modeling Parkinson's disease and amyotrophic lateral sclerosis in vitro.

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Applications
Cellular Dynamics

Using LEAP to Measure Cardiac Action Potential Morphology

See the newly launched protocol for Local Extracellular Action Potential (LEAP) measurements of plated iCell Cardiomyocytes2 and how this method provides a more robust, high-sensitivity measurement of ion channel activity in safety pharmacology and automated detection and classification of arrhythmias.

SEE THE PROTOCOL >>

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