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November 2020EventsPublications

See the 2020 NANION User Meeting Presentations

Discover advances and perspectives in the field of electrophysiology in these data-driven talks that discuss:

  • Membrane physiology beyond Ion channels
  • Ligand-gated ion channels in drug discovery
  • Cardiac safety testing from Ion channels to human heart
  • Voltage-gated ion channels
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A New Validated Human iPSC-Derived Cardiomyocyte Line for Diversification of Donor Responses in Drug Discovery and Safety Pharmacology Studies

Hear about footprint-free iCell® Cardiomyocytes2, 11713 and their response to the CiPA-28 reference compounds and a new protocol for the quantitation of action potential morphology and automated detection and classification of arrhythmias. Now available on demand.

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Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Learn about the characterization and iPSC-derived dopaminergic and motor neurons modeling Parkinson's disease and amyotrophic lateral sclerosis in vitro, using HD-MEAs.

The presentation includes the metrics used for phenotype characterization and data demonstrating how HD-MEAs supply the ability to detect drug effects.

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FUJIFILM Cellular Dynamics

Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

McKeithan WL, Feyen D, Bruyneel A, et al. (2020) Cell Stem Cell. 2020;27(5) 813-821.e6 .

Read how researchers performed chemical refinement of the antiarrhythmic drug mexiletine via high-throughput screening. Their method used human iPSC-derived MyCell Cardiomyocytes LQT3 SCN5A F1473C produced from patients with long QT syndrome 3.

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Microdose Lithium Reduces Cellular Senescence in Human Astrocytes - A Potential Pharmacotherapy for COVID-19?

Viel T, Chinta S, Rane A, Chamoli M, Buck H, Andersen J. Aging (Albany NY). 12(11):10035-10040.

Delve into research showing how low-dose lithium reduced the release of a senescence associated secretory phenotype (SASP) in iCell Astroyctes following acute treatment. The findings suggest that microdose lithium could protect cells from senescence and development of aging-related conditions.

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FUJIFILM Cellular Dynamics

FUJIFILM Cellular Dynamics

Mitomycin-C Treatment during Differentiation of Induced Pluripotent Stem Cell-derived Dopamine Neurons Reduces Proliferation without Compromising Survival or Function In Vivo

Hiller BM, Marmion DJ, Gross RM, et al. (2020) Stem Cell Transl Med. 2020;1-13.

See how this optimized protocol for the production of midbrain dopamine neurons generated an optimized, low proliferation population suitable for Parkinson's disease cell therapeutic development and testing in animal models.

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