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August 2021 FCDI NotebookEventsPublications
FUJIFILM Cellular Dynamics

2021 Nanion User Meeting

Join the Nanion User Meeting in person or virtually (livestream) to learn about the advances, applications and perspective in the field of electrophysiology. FCDI plans to participate and share some of our collaborative activities and projects.

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Micro-Electrode Channel Guide (µECG) Technology: An Online Method for Continuous Electrical Recording in a Human Beating Heart-on-Chip

Visone R, Ugolini GS, et al. Biofabrication. 2021 Feb 9. Epub ahead of print. PMID: 33561845.

Learn about a new device capable of continuous monitoring of electrophysiological signals from functional in vitro human hearts-on-chip, using micro-electrode coaxial guides (µECG). The human cardiac microtissues exhibited synchronous, spontaneous beating and expression of cardiac ion-channels. See the validation data on 3 test compounds.

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FUJIFILM Cellular Dynamics

FUJIFILM Cellular Dynamics

Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell Derived) Cardiomyocytes

Christina Schmid, Najah Abi-Gerges, Dietmar Zellner, Georg Rast doi:

This study used a single-cell patch-clamp-RT-qPCR approach to get insights into single-cell electrophysiology and ion channel expression using commercially available iCell®  Cardiomyocytes, and primary human adult atrial and ventricular cardiomyocytes. See the results in this preprint article.

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Chronic Cardiotoxicity Assessment of BMS-986094, a Guanosine Nucleotide Analogue, Using Human iPS Cell-Derived Cardiomyocytes

Yanagida S, Satsuka A, Hayashi S, Ono A, Kanda Y. J Toxicol Sci. 2021;46(8):359-369. PMID: 34334557.

This research group compared the cardiotoxic effects of the anti-hepatitis C virus (HCV) drug BMS-986094, a candidate which was withdrawn because of cardiotoxicity, with sofosbuvir, another nucleotide analogue inhibitor of HCV that has been approved, using  iPSC-derived cardiomyocytes. See how this method differentiated cardiotoxicity between the two drugs.

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FUJIFILM Cellular Dynamics

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